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Previously, people that were taking Cardarine alone experienced a gradual decrease in their fat cells, but they also had to grapple with the fact that they would also be losing some musclemass. The team at MIT and Stanford looked at the effects of short-term and long-term Cardarine use on body composition in the rats. Although the rats were not on an active low-carb diet, they were given diets that included about 60 grams of saturated fat per day. They had been treated with either an isocaloric combination of Cardarine, a calorie-reduced diet or a high- carbohydrate, low-fat diet. The rats were then placed on a low-carb diet for four days and then back on a standard low-fat diet for four days. When the researchers looked at body composition, they saw that even though Cardarine's effects lasted for as much as 10 days, the rats remained leaner than previously. A second study used insulin and leptin levels to see whether there was a relationship between the amount of Cardarine and the effects on body composition that the rats had. Insulin levels fell during the first week of treatment but rose later in the treatment period. But when leptin levels were measured, the researchers saw that rats that took Cardarine during the first week had lower testosterone and DHEA levels. "In other words, they were losing fat storage, but they were also gaining more lean muscle mass," says study coauthor Eric Schlosser, post-doc professor in the Department of Pharmacology at Stanford. The researchers also note that because Cardarine has two nutrients in it, there isn't even any comparison to be made between Cardarine and other fat-burning supplements that don't incorporate two nutrients. "You can't say that Cardarine is exactly like some other supplement," says Schlosser. Future work on this research should explore both low-carb diets and diets with higher levels of carbohydrates and fats, says Schlosser. "It may be necessary for additional studies to consider what other changes are occurring in the system, such as insulin sensitivity, as well as other changes such as fatty acid uptake into mitochondria by the liver in order to better understand how these two different dietary interventions impact the body's fat loss." To conduct the study, the researchers used eight healthy male rats, ranging from 4 to 18 months of age. They fed each of the rats a standard low-carb diet and also a high-carb diet. Each rat was given a daily intravenous injection of lipids and hormones. The researchers measured their fat levels, insulin levels and leptin levels over the course of a week using ultrasensitive blood tests. Similar articles:
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